Sensoril® patented, full-spectrum standardized root and leaf extract of Ashwagandha or Withania somnifera, a popular herb that has been used for centuries in Auyervedic medicine and is commonly referred to by practicioners as the King of Ayurveda. Ashwagandha translates from Sanskrit to “smell of horse”, referring to the distinctly horsey, farmhouse odor, and according to folklore, it is thought eating the herb delivers the strength and vitality of a horse (5).
Ashwagandha is considered an adaptogen, meaning that it helps the body adapt to anxiety and stress on both a physiological and psychological level (7). Today, ashwagandha is mainly known for its positive effects on helping the body cope with stress, increase endurance, and enhance cognitive function (namely improved memory as a result of reduced anxiety) (6). It has been shown to alleviate the effects of insomnia and stress-related depression (8). It can reduce cortisol levels (the stress hormone) and the immunosuppressive effects of stress (9). As a cognitive enhancing supplement, ashwagandha may be effective in treating Alzheimer’s disease and improving memory formation (10).
In addition, Ayurveda uses Ashwagandha to treat tumors and ulcers (3), to enhance virility and as an aphrodisiac, as a rejuvenating agent, as well as to treat inflammation, fatigue, stress, diabetes, cardiovascular disease, and more (4), and may confer neuroprotective and anticancer benefits (2). The herb also has some interesting implications as an anti-cancer treatment; research suggests it may serve as an effective adjuvant therapy, used alongside other primary forms of cancer treatment (11).
Ashwagandha contains a large number of biologically active compounds including polyphenols, antioxidants, and other molecules that act upon different mechanisms and enzymatic pathways in the body (12). Ashwagandha supports mechanisms that suppress metastasis and angiogenesis, upon various neuroprotective pathways in the brain involved such as the cholinergic system, dopaminergic, and glutaminergic system, and it interacts with proteins and enzymes involved in reducing inflammation and maintaining cellular integrity (13, 14, 15, 16). Though we know many of the pathways ashwagandha acts upon, many have yet to be elucidated by scientific investigation.
Sensoril has been clinically shown to reduce circulating levels of cortisol and importantly, C-Reactive Protein a marker of systemic inflammation. Sensoril also lowered subjects pulse rates and blood pressure compared to a placebo. They also had increases in DHEA (an important hormone related to memory and mood) and hemoglobin. Compared to the control group, subjects reported fewer headaches, less fatigue, muscle pain, sleeplessness, forgetfulness and irritability, plus better appetite and concentration. There were no reports of adverse side effects. The clinical dose of Sensoril to achieve these results is 125mg.