L-Theanine is a naturally occurring amino acid found in green tea leaves. Its chemical structure is similar to the neurotransmitter Glutamate. L-Theanine's similarity to Glutamate, one of the two key compounds responsible for signal transmission in the brain, makes L-Theanine valuable as a nootropic supporting overall learning, focus, and memory. L-Theanine is also shown to increase the brain’s levels of dopamine and serotonin, reducing feelings of stress and enhancing general well-being. L-Theanine combines well with caffeine, boosting the combination’s effect on focus and alertness while decreasing jittery and stressful effects.

Theacrine is an alkaloid compound similar to caffeine but with novel differences. Like caffeine, theacrine promotes energy, alertness, and focus, and it also reduces occasional fatigue. But unlike caffeine, the effects taper off gradually and last longer, and – surprisingly – theacrine seems to have a relaxing and anti-stress effect. Also important is that tolerance to theacrine develops slowly if at all. Theacrine’s benefits are enhanced when it is combined with caffeine.